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Frequency, Burden and Pathogens of Acute Respiratory Illness in Very Preterm Infants During Infancy

To describe the frequency, burden, and pathogen profile of acute respiratory illnesses in very preterm infants during the first year after neonatal i…

Trial Steering Committee

The CIRCA DIEM Trial Steering Committee provides independent oversight and strategic guidance for the study.

Data Safety Monitoring Committee

The Data Safety Monitoring Committee (DSMC) is an independent group of experts that oversees participant safety and the integrity of the CIRCA DIEM S…

The CIRCA DIEM Biobank

The CIRCA DIEM biobank is a unique collection of biological samples - such as blood, stool and saliva - collected from babies enrolled in the trial.

CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever

The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and pr…

Prognostic Accuracy of BPD Definitions for Long-Term Outcomes in Preterm Infants: A Systematic Review

Since the first description of bronchopulmonary dysplasia (BPD), multiple definitions to diagnose BPD and its grading have been published. Several st…

Interleukin-4 modulates type I interferon to augment antitumor immunity

Despite advances in immunotherapy, metastatic melanoma remains a considerable therapeutic challenge due to the complexity of the tumor microenvironme…

Diaphragm Function in Very Preterm Infants at 36 Weeks' Postmenstrual Age

Understand how bronchopulmonary dysplasia (BPD) and antenatal and postnatal factors influence diaphragmatic functional effectiveness in very preterm…

Comparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial)

Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surf…