Posaconazole is a triazole antifungal with a broad spectrum of activity against moulds including Aspergillus spp. Emerging data suggest posaconazole…
Aspergillus is increasingly associated with lung inflammation and mucus plugging in early cystic fibrosis disease during which conidia burden is low…
Despite advances in cystic fibrosis (CF) management and survival, the optimal treatment of pulmonary exacerbations remains unclear. Understanding the…
Sensitive and non-invasive surveillance tools are needed for the clinical management of infants and preschool children with cystic fibrosis (CF). The…
The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbal…
Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estim…
There is no consensus on how best to measure responses to interventions among children and adults with cystic fibrosis (CF). We have systematically r…
Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout pres…
In this cohort, as compared with the AREST CF cohort, the authors highlight the limited correlation between infection and inflammation with lung func…